Indianapolis Colts vs San Francisco 49ers – Schedule & Where to Watch on TV

22/12/2025 at 20:15 (Time Zone – GMT-5 (America/New_York))

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Indianapolis Colts
31.2%

San Francisco 49ers
68.8%

(when we started the analysis)

29.4%

70.6%

29.5%

70.5%

	1	X	2	Marga
Avarage Now (Initially)	3.04 ↓ (3.24)		1.39 ↑ (1.35)	5.1% (5%)

A mid-table team takes on a leader in this match (ranked 7 and 3).
Indianapolis is going through a rough patch (last 5 games: 1 wins).
San Francisco is showing top-class performance now (in the last 5 games, wins – 4).
In this match, San Francisco is the team to beat.
We predict that San Francisco will win today's game, with odds of 1.38.
In the last 4 head-to-head matches, Indianapolis won 4 matches, drew 0 matches, lost 0 matches, and goals 106:65. (average 26.5:16.3).
Including home matches between the teams, Indianapolis won 2 matches, drew 0 matches, lost 0 matches, and goals 49:40. (average 24.5:20).

Indianapolis Colts has won of their last 0 head-to-head matches.

San Francisco 49ers has won of their last 0 head-to-head matches.

The latest head-to-head matches between Indianapolis Colts - San Francisco 49ers were as follows:

14.12.2025 Seattle Seahawks - Indianapolis Colts 18:16 ✺

07.12.2025 Jacksonville Jaguars - Indianapolis Colts 36:19 ✺

30.11.2025 Indianapolis Colts - Houston Texans 16:20 ✺

23.11.2025 Kansas City Chiefs - Indianapolis Colts 23:20 ✺

09.11.2025 Indianapolis Colts - Atlanta Falcons 31:25 ✺

14.12.2025 San Francisco 49ers - Tennessee Titans 37:24 ✺

30.11.2025 Cleveland Browns - San Francisco 49ers 8:26 ✺

24.11.2025 San Francisco 49ers - Carolina Panthers 20:9 ✺

16.11.2025 Arizona Cardinals - San Francisco 49ers 22:41 ✺

09.11.2025 San Francisco 49ers - Los Angeles Rams 26:42 ✺

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