Time Zone – GMT-4 (America/New_York)
| 1 | MLS All-Stars | Liga MX All-Stars |
| Pl | W | D | L | Diff | Pts | |||
| 1 | San Diego FC | 24 | 13 | 4 | 7 | 47:32 | 15 | 43 |
| 2 | Vancouver Whitecaps | 23 | 12 | 6 | 5 | 39:26 | 13 | 42 |
| 3 | Minnesota United | 24 | 11 | 8 | 5 | 40:27 | 13 | 41 |
| 4 | Seattle Sounders | 23 | 10 | 7 | 6 | 37:33 | 4 | 37 |
| 5 | Los Angeles FC | 21 | 10 | 6 | 5 | 39:27 | 12 | 36 |
| 6 | Portland Timbers | 23 | 9 | 7 | 7 | 32:32 | 0 | 34 |
| 7 | Colorado Rapids | 24 | 8 | 6 | 10 | 30:36 | -6 | 30 |
| 8 | Austin FC | 22 | 8 | 6 | 8 | 17:24 | -7 | 30 |
| 9 | San Jose Earthquakes | 24 | 7 | 8 | 9 | 46:42 | 4 | 29 |
| 10 | Real Salt Lake | 23 | 8 | 4 | 11 | 24:29 | -5 | 28 |
| 11 | Houston Dynamo | 24 | 7 | 6 | 11 | 30:39 | -9 | 27 |
| 12 | FC Dallas | 23 | 6 | 7 | 10 | 32:41 | -9 | 25 |
| 13 | Sporting Kansas City | 23 | 6 | 6 | 11 | 36:42 | -6 | 24 |
| 14 | St. Louis City | 23 | 4 | 6 | 13 | 23:38 | -15 | 18 |
| 15 | Los Angeles Galaxy | 24 | 3 | 7 | 14 | 28:48 | -20 | 16 |
| Pl | W | D | L | Diff | Pts | |||
| 1 | FC Cincinnati | 24 | 15 | 3 | 6 | 39:31 | 8 | 48 |
| 2 | Nashville SC | 24 | 14 | 5 | 5 | 42:25 | 17 | 47 |
| 3 | Philadelphia Union | 24 | 14 | 5 | 5 | 40:23 | 17 | 47 |
| 4 | Columbus Crew | 24 | 12 | 8 | 4 | 40:33 | 7 | 44 |
| 5 | Inter Miami | 21 | 12 | 5 | 4 | 49:34 | 15 | 41 |
| 6 | Orlando City | 24 | 10 | 8 | 6 | 43:32 | 11 | 38 |
| 7 | Charlotte | 24 | 11 | 2 | 11 | 41:39 | 2 | 35 |
| 8 | New York City | 23 | 10 | 5 | 8 | 30:26 | 4 | 35 |
| 9 | New York Red Bulls | 24 | 9 | 6 | 9 | 39:35 | 4 | 33 |
| 10 | Chicago Fire | 23 | 9 | 5 | 9 | 44:40 | 4 | 32 |
| 11 | New England Revolution | 23 | 6 | 7 | 10 | 30:32 | -2 | 25 |
| 12 | Toronto FC | 23 | 5 | 6 | 12 | 25:30 | -5 | 21 |
| 13 | Atlanta Utd | 23 | 4 | 8 | 11 | 27:43 | -16 | 20 |
| 14 | DC United | 24 | 4 | 7 | 13 | 20:45 | -25 | 19 |
| 15 | CF Montreal | 24 | 3 | 6 | 15 | 20:45 | -25 | 15 |
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