Time Zone – GMT-4 (America/New_York)
| 1 | MLS All-Stars | Liga MX All-Stars | 3 : 1 |
| Pl | W | D | L | Diff | Pts | |||
| 1 | San Diego FC | 28 | 16 | 5 | 7 | 52:33 | 19 | 53 |
| 2 | Minnesota United | 29 | 14 | 9 | 6 | 48:32 | 16 | 51 |
| 3 | Vancouver Whitecaps | 27 | 14 | 7 | 6 | 47:31 | 16 | 49 |
| 4 | Seattle Sounders | 27 | 12 | 8 | 7 | 48:38 | 10 | 44 |
| 5 | Los Angeles FC | 25 | 11 | 8 | 6 | 44:31 | 13 | 41 |
| 6 | Portland Timbers | 28 | 10 | 9 | 9 | 36:38 | -2 | 39 |
| 7 | Austin FC | 27 | 10 | 8 | 9 | 29:33 | -4 | 38 |
| 8 | Colorado Rapids | 29 | 10 | 6 | 13 | 38:48 | -10 | 36 |
| 9 | San Jose Earthquakes | 29 | 9 | 8 | 12 | 53:51 | 2 | 35 |
| 10 | Houston Dynamo | 28 | 8 | 8 | 12 | 37:46 | -9 | 32 |
| 11 | Real Salt Lake | 27 | 9 | 4 | 14 | 28:36 | -8 | 31 |
| 12 | FC Dallas | 27 | 7 | 9 | 11 | 39:47 | -8 | 30 |
| 13 | Sporting Kansas City | 28 | 7 | 6 | 15 | 43:57 | -14 | 27 |
| 14 | St. Louis City | 28 | 5 | 6 | 17 | 33:50 | -17 | 21 |
| 15 | Los Angeles Galaxy | 27 | 4 | 7 | 16 | 32:55 | -23 | 19 |
| Pl | W | D | L | Diff | Pts | |||
| 1 | Philadelphia Union | 29 | 17 | 6 | 6 | 49:26 | 23 | 57 |
| 2 | FC Cincinnati | 29 | 16 | 4 | 9 | 42:36 | 6 | 52 |
| 3 | Charlotte | 29 | 16 | 2 | 11 | 48:40 | 8 | 50 |
| 4 | Nashville SC | 29 | 15 | 5 | 9 | 49:33 | 16 | 50 |
| 5 | Orlando City | 28 | 13 | 8 | 7 | 54:40 | 14 | 47 |
| 6 | Inter Miami | 25 | 13 | 7 | 5 | 54:40 | 14 | 46 |
| 7 | Columbus Crew | 28 | 12 | 10 | 6 | 43:39 | 4 | 46 |
| 8 | New York City | 27 | 13 | 5 | 9 | 38:32 | 6 | 44 |
| 9 | New York Red Bulls | 29 | 11 | 7 | 11 | 42:38 | 4 | 40 |
| 10 | Chicago Fire | 27 | 11 | 6 | 10 | 50:48 | 2 | 39 |
| 11 | New England Revolution | 28 | 8 | 7 | 13 | 36:40 | -4 | 31 |
| 12 | Atlanta Utd | 28 | 5 | 11 | 12 | 32:49 | -17 | 26 |
| 13 | Toronto FC | 28 | 5 | 10 | 13 | 28:35 | -7 | 25 |
| 14 | CF Montreal | 29 | 5 | 9 | 15 | 29:51 | -22 | 24 |
| 15 | DC United | 29 | 5 | 9 | 15 | 26:54 | -28 | 24 |
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